Let's sample some of the results of my experimentation...
Here are some scans:
This is hand-drawn, first drafted with a regular pencil, then more-or-less-inked using pens. As you can see I don't really know what to do with the brush-like pen I bought so I tried using it to make some lines stronger but it didn't work too well.
I didn't erase the pencil, so you can actually see what I changed.
Then, I scanned this and put it on a layer in Inkscape (actually although the above is a scan, I used a photo because I didn't have the scanner at hand). After that I used mostly the pen tool to draw the lines, and the calligraphy tool for most of the shading, all inside Inkscape.
In fact, the above is one of my favorite panels so far.
Then, the following was drawn directly using Calligraphy tool, as a sketch:
Finally, I took that same drawing directly and just added some shading and a bit of color here and there, and fixed some things (mostly when lines crossed each other).
I particularly prefer the second option, but just because the rest of the comic looks like that. I think I could do some story using just those pseudo-drafts, with minor tweaking for shading. This last one is also nice and has the advantage of being the fastest of all, as you work digitally during all the process.